影響多肽與亞鐵螯合能力的關(guān)鍵因素

研究表明多肽的氨基酸組成、排列、分子量等因素，均會影響其亞鐵螯合能力，其中氨基酸組成和排列是最重要的影響因素。一般來說，具有亞鐵離子螯合活性的多肽大都含有半胱氨酸、組氨酸、絲氨酸、天冬氨酸和谷氨酸等氨基酸。多肽的分子量是影響螯合性能和穩(wěn)定性的重要因素。越來越多的研究顯示低分子量的多肽與亞鐵離子具有更高的螯合能力。研究發(fā)現(xiàn)，一些氨基酸與亞鐵離子的螯合能力是氨基酸上的特殊基團決定的。當某些氨基酸殘基位于 N-末端或 C-末端時，多肽的亞鐵螯合活性被 增強，位于 N-末端的組氨酸殘基多肽的金屬螯合能力比位于 C-末端的強。酸性氨基酸、堿性氨基酸和一些特殊氨基酸對亞鐵離子有很強的螯合能力。例如，組氨酸和谷氨酸分別以咪唑環(huán)、 γ-COO-提供了更多的鐵結(jié)合位點，從而具有較好的螯合能力。

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抗壞血酸亞鐵Ferrous Ascorbate、賴氨酸甘氨酸鎂Magnesium Lysinate Glycinate、甘氨酸谷氨酰胺鎂Magnesium Glycinate Glutamine、檸檬酸蘋果酸鎂Magnesium Citrate Malate、檸檬酸鍶Strontium Citrate、檸檬酸錳Manganese Citrate、檸檬酸銅Copper Citrate、天門冬氨酸鋰Lithium Aspartate、抗壞血酸錳Manganese Ascorbate、牛磺酸硒Selenium Taurate。

The key factors influencing the chelating ability of polypeptides to ferrous

Studies have shown that the amino acid composition, arrangement and molecular weight of polypeptides can affect their ferrous chelating ability, among which the amino acid composition and arrangement are the most important factors. In general, polypeptides with ferrous ion chelating activity mostly contain amino acids such as cysteine, histidine, serine, aspartate and glutamic acid. The molecular weight of peptides is an important factor affecting the chelation performance and stability. More and more studies have shown that low molecular weight polypeptides have higher chelation ability with ferrous ions. It has been found that the chelating ability of some amino acids with ferrous ions is determined by special groups on amino acids. When some amino acid residues are located at the N-terminal or C-terminal, the ferrous chelating activity of the polypeptide is enhanced, and the metal chelating ability of the histidine residues in the n-terminal is stronger than that in the C-terminal. Acidic amino acids, basic amino acids and some special amino acids have strong chelating ability to ferrous ions. For example, histidine and glutamate provide more iron-binding sites in imidazole ring and gamma-COO -, respectively, and thus have better chelating ability.

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Ferrous Ascorbate, Magnesium Lysinate Glycinate, Magnesium lysinate Glycinate Glutamine, Magnesium citrate malate Citrate Malate, Strontium Citrate, Manganese Citrate, Copper Citrate, Lithium Aspartate, Manganese ascorbate Ascorbate, Selenium Taurate.